The Link Between Alzheimer’s Disease and Gut Microbiome

In a recent YouTube video, Dr. Misha Kogan from the GW Center for Integrative Medicine discussed an intriguing correlation between Alzheimer’s disease and disturbances in the gut microbiome. This article delves into the key points raised in the video, highlighting a study on the gut microbiome’s potential indicators for Alzheimer’s disease and a case study illustrating the impact of addressing gut health on cognitive decline. The research suggests a strong connection between the gut microbiome and the risk of Alzheimer’s, prompting further investigation and potential treatment avenues.

Photo of Dr. Misha Kogan explaining data from a study on gut microbiom

The Study: Gut Microbiome Composition and Clinical Alzheimer’s Disease

The video highlights a study published in the journal of Science Translational Medicine, which examined the gut microbiome composition as a potential indicator for clinical Alzheimer’s disease. The study involved a significant number of participants, with 164 cognitively normal patients and 49 patients with Alzheimer’s disease.

The researchers analyzed stool samples and assessed microbiome composition, along with other factors such as cognitive scores, hippocampal volume, and levels of abnormal proteins in cerebrospinal fluid. The study aimed to provide valuable insights into the correlation between gut microbiome composition and Alzheimer’s risk.

Findings and Implications:

The study revealed significant differences in the gut microbiome between patients with Alzheimer’s disease and cognitively normal individuals. Certain types of bacteria were more prevalent in patients with Alzheimer’s, while others, like

Human microbiome
Certain types of bacteria were more prevalent in patients with Alzheimer’s, while others, like bifidobacteria, were less prevalent.

bifidobacteria, were less prevalent. Additionally, specific biochemical changes in the stool, such as degradation of amino acids and low levels of short-chain fatty acids, were strongly linked to a higher risk of Alzheimer’s.

Though the study’s plots and data interpretation can be complex, it underscores the importance of understanding the gut microbiome’s role in Alzheimer’s disease. These findings provide a foundation for future research and potential interventions.

Case Study: Addressing Gut Health and Cognitive Decline

Dr. Kogan shares a case study of a 77-year-old man with early-stage Alzheimer’s disease and chronic irritable bowel syndrome (IBS). After undergoing a gut microbiome test, the patient’s stool results revealed significant mal-processing and low levels of beneficial bacteria, such as bifidobacteria.

By addressing the patient’s gastrointestinal symptoms and implementing personalized interventions, the patient experienced improvements in both IBS symptoms and cognitive well-being. This case study demonstrates the potential benefits of targeting gut health as part of a comprehensive approach to treating early-stage Alzheimer’s disease.

Implications for Treatment and Future Research

While further research is needed to understand the full extent of the gut-brain connection and its implications for Alzheimer’s disease, the study and case study discussed in the video highlight the importance of considering gut health in Alzheimer’s prevention and management.

Certain steps can be taken to improve gut health:

  1. Addressing overgrowth of certain bacteria: Cutting out foods that promote bacterial overgrowth, such as high fructose oligosaccharides or FODMAPs, and using antimicrobials if necessary.
  2. Promoting beneficial bacteria growth: Consuming foods rich in specific types of fiber and antioxidants that support the growth of beneficial bacteria.

    Healthy foods for healthy gut
    Consume foods rich in fiber and antioxidants to support the growth of beneficial bacteria.
  3. Avoiding detrimental foods: Eliminating simple carbohydrates, sugars, and refined flour, which can disrupt the balance of the gut microbiome.

While the use of probiotics has been explored, there is currently limited evidence
to support their effectiveness in treating Alzheimer’s disease. However, the emerging field of fecal microbiota transplantation (FMT) shows promise. FMT involves transferring stool from a healthy individual to the one with an imbalanced gut microbiome.

Ongoing research, including the clinical trial mentioned by Dr. Kogan’s team, aims to further investigate the potential of personalized interventions based on gut microbiome analysis. These studies may pave the way for future treatments and approaches to managing Alzheimer’s disease.


The link between the gut microbiome and Alzheimer’s disease is an area of growing interest in scientific research. The discussed study and case study shed light on the potential significance of the gut-brain axis in understanding and managing Alzheimer’s disease. By acknowledging the connection between gut health and cognitive decline, researchers and medical professionals strive to develop innovative strategies for prevention, early detection, and treatment of this debilitating disease.

For more information on the gut health study: Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease

Alzheimer’s Treatment in Washington, D.C. 

Dr. Kogan, a leader in Integrative Geriatrics, and his team at GWCIM offer the ReCODE program (The Dr. Bredesen protocol™ and the ReCODE Protocol™) for Alzheimer treatment.  As to date, The GW Center has treated over 60 patients with Alzheimer’s Disease in the reversal of cognitive decline.